Top Principal Software Engineer Jobs in San Francisco, CA

As a Principal Software Engineer, you'll architect scalable backend systems for mobile applications, mentor teams, and influence tech strategy to support mobile-first growth.

Lead the development of core data platform capabilities at Benchling. Design data architecture, mentor engineers, and implement scalable data solutions across biotech companies.

The Principal Backend Software Engineer leads complex architecture projects, unblocks development challenges, and mentors junior engineers while ensuring high-quality code standards.

Responsible for architecting and modernizing Salesforce's data ecosystem, optimizing performance, and leading design for AI and knowledge graph integration.

The Principal Software Engineer will lead application development for M&A and Operations, focusing on backend architecture, coding quality, and testing methodologies, while managing junior engineers and enhancing system integration.

Lead the design and operation of the Gradient AI platform, focusing on scalability, performance, and innovation in agent development. Mentor engineers and collaborate across teams to deliver strategic technical roadmaps and enhance operational excellence.

As a Principal Software Engineer, you'll lead architectural strategies, mentor engineers, prototype services, and ensure alignment with business goals in a remote environment.

The Principal Software Engineer leads technical standards and product design in a collaborative hybrid environment, focusing on complex software solutions, cloud services, and mentoring teams.

The Principal Full Stack Software Engineer will lead technical direction, collaborate with teams, mentor engineers, and ensure high-quality code for SaaS products.

The Principal Software Engineer will define technical roadmaps, guide system architecture, mentor leaders, and drive product direction in Capital Supply operations.

Lead the design and development of large-scale perception systems for an autonomous driving platform, focusing on optimizing resource sharing and performance.

As an iOS Software Engineer, improve the iOS app infrastructure, streamline processes, and maintain app releases while mentoring junior engineers.

The Principal Engineer will lead the design and delivery of AI solutions, mentor engineers, and align global AI architectures, focusing on applied AI and agentic AI platforms.

Lead the development of software solutions for Early Clinical Development, mentor engineers, and drive technical strategies for clinical trial data and AI/ML integration.

As a Software Engineer, you will enhance computational and data ecosystems, develop scalable systems, and integrate AI to accelerate drug discovery.

Lead the development of healthcare software, manage a team of engineers, and collaborate on architecture and product requirements while maintaining high standards of quality and security.

Lead a software engineering team to develop healthcare software, mentoring members, collaborating closely with product and design teams, and ensuring high-quality delivery.

As a Principal Software Engineer, you will lead technical vision for Generative AI, mentor engineers, and drive impactful multi-year AI projects.

Lead the technical vision and architecture for a lending platform, ensuring design of scalable, secure systems. Mentor teams and drive innovation in fintech solutions.

The Principal Software Engineer, Payments, leads design and architecture of Turo's payment systems, mentors engineers, and collaborates with cross-functional teams to ensure operational excellence.

The Staff/Principal Software Engineer will lead the development of full-text search capabilities, focusing on search infrastructure, collaboration, and innovative solutions in AI applications at Pinecone.

Seeking a Principal Software Engineer to build developer products for LLM applications, ensuring high-quality tools and APIs while leading engineering practices and collaborating across teams.

The Principal Software Engineer will provide technical and architectural leadership in data engineering, focusing on strategy, innovation, and ensuring successful production deliveries while fostering teamwork and mentoring.

Lead design and implementation of Generative AI features, mentor engineers, ensure performance and reliability, collaborate with product teams, and maintain high quality standards.

The Principal Software Engineer, Applied AI will lead the integration of AI into data apps, mentor teams, and ensure system reliability at scale through full stack development using React and Python.