Top Principal Software Engineer Jobs in San Francisco, CA

As a Principal Software Engineer, you'll architect scalable backend systems for mobile applications, mentor teams, and influence tech strategy to support mobile-first growth.

The Principal Software Engineer leads technical standards and product design in a collaborative hybrid environment, focusing on complex software solutions, cloud services, and mentoring teams.

You will lead the development of key platform components at Onos Health, focusing on healthcare data integrations, architectural decisions, and team growth while collaborating closely with machine learning engineers.

Lead the development of core data platform capabilities at Benchling. Design data architecture, mentor engineers, and implement scalable data solutions across biotech companies.

The Principal Backend Software Engineer leads complex architecture projects, unblocks development challenges, and mentors junior engineers while ensuring high-quality code standards.

The Principal Software Engineer will lead application development for M&A and Operations, focusing on backend architecture, coding quality, and testing methodologies, while managing junior engineers and enhancing system integration.

Lead the design and operation of the Gradient AI platform, focusing on scalability, performance, and innovation in agent development. Mentor engineers and collaborate across teams to deliver strategic technical roadmaps and enhance operational excellence.

As a Principal Software Engineer, you'll lead architectural strategies, mentor engineers, prototype services, and ensure alignment with business goals in a remote environment.

The Principal Full Stack Software Engineer will lead technical direction, collaborate with teams, mentor engineers, and ensure high-quality code for SaaS products.

The Principal Software Engineer will define technical roadmaps, guide system architecture, mentor leaders, and drive product direction in Capital Supply operations.

Lead mobile software development as a Principal Mobile Software Engineer, driving technical strategy, building systems in React Native, and mentoring engineers to enhance user experience and scalability.

Lead the design and development of large-scale perception systems for an autonomous driving platform, focusing on optimizing resource sharing and performance.

As an iOS Software Engineer, improve the iOS app infrastructure, streamline processes, and maintain app releases while mentoring junior engineers.

The Principal Engineer will lead the design and delivery of AI solutions, mentor engineers, and align global AI architectures, focusing on applied AI and agentic AI platforms.

Lead the development of software solutions for Early Clinical Development, mentor engineers, and drive technical strategies for clinical trial data and AI/ML integration.

Lead design and implementation of Generative AI features, mentor engineers, ensure performance and reliability, collaborate with product teams, and maintain high quality standards.

The Principal Software Engineer will define technical direction, design scalable systems for identity verification, and mentor engineers at Nametag.

As a Software Engineer, you will enhance computational and data ecosystems, develop scalable systems, and integrate AI to accelerate drug discovery.

Lead the development of healthcare software, manage a team of engineers, and collaborate on architecture and product requirements while maintaining high standards of quality and security.

Lead a software engineering team to develop healthcare software, mentoring members, collaborating closely with product and design teams, and ensuring high-quality delivery.

As a Principal Software Engineer on the GenAI team, lead the design and implementation of AI-powered solutions, ensuring technical alignment and mentoring engineers.

As a Senior Principal Software Engineer, you'll develop a unified data platform, architect infrastructure, implement APIs, and mentor teams, focusing on data processing and reliability.

The Principal Software Engineer guides technical vision, leads projects, mentors engineers, and develops complex software solutions across various domains.

As a Principal Software Engineer, you will lead technical vision for Generative AI, mentor engineers, and drive impactful multi-year AI projects.

The Principal Engineer will lead the architectural vision for the TiDB optimizer, focusing on query optimization and enhancing the performance of the TiDB database, employed by large organizations globally.